Methadone Clinics in Missouri

Name rehabsAddressPhone
Alternative Opportunities Inc Carol Jones Recovery Center for Women2411 West Catalpa Street Springfield, MO 65807(417) 862-3455x13
Barnes Jewish Hospital Chemical Dependency Program1 Barnes Jewish Hospital Plaza Saint Louis, MO 63110(314) 362-8884
Behavioral Health Group - Columbia Medical Clinic 1301 Vandiver Square Suite Y Columbia, MO 65202
Behavioral Health Group - Joplin Treatment Clinic 2919 East 4th Street Joplin, MO 64801
Behavioral Health Group - Kansas City Medical Clinic 723 East 18th Street Kansas City, MO 64108
Behavioral Health Group - Springfield Medical Clinic 404 East Battlefield Road Springfield, MO 65807
Bridgeway Counseling Services Inc1027 South Vandeventer Avenue Saint Louis, MO 63110(314) 652-4200
Cape Girardeau Treatment Center 760 S. Kings Highway Suite F Cape Girardeau, MO 63703
Center for Addictions Cox Health1423 North Jefferson Street Springfield, MO 65802(417) 269-2273
Center for Life Solution Inc II Medication Unit637 Dunn Road Suite 180 Hazelwood, MO 63042(314) 731-0100

Rules and regulations

Missouri adheres to strict federal and state regulations regarding methadone clinics, outlined by the Substance Abuse and Mental Health Services Administration (SAMHSA) and Missouri Department of Mental Health. All clinics must be licensed and accredited.

Certification procedures

To open a new opioid treatment program in Missouri:

  • Submit application to state opioid treatment authority
  • Undergo facility inspections, plan reviews
  • Demonstrate capacity to provide required services
  • Have certified medical director and staff
  • Meet security standards

Benefits of medication-assisted treatment

Benefits of methadone maintenance therapy include:

  • Reducing opioid cravings and withdrawal
  • Allowing focus on recovery and rehabilitation
  • Lowering risk of overdose and infectious disease
  • Improving overall health and functioning

How clinics operate and their purpose

Methadone clinics provide supervised methadone dosing, counseling, case management to support recovery from opioid addiction. The goal is harm reduction and improved wellbeing.

Insurance Coverage

  • Missouri Medicaid covers methadone treatment
  • Some private insurers may offer limited coverage
  • Uninsured individuals may qualify for state-funded treatment slots

Drug Use in Missouri

  • Over 1,700 opioid overdose deaths in 2020, a 34% jump since 2019, declared a public health crisis
  • Over 500,000 people reported misusing prescription opioids from 2015-2019
  • Methamphetamine, alcohol, cocaine, and cannabis also widely used

Addiction Treatment Overview

Inpatient Treatment

  • Focuses on medical stabilization, counseling, group therapy in a residential facility
  • Typical stay is 30 days

Outpatient Treatment

  • Services while living at home – counseling, medication management
  • 1-5 days a week for several hours per day

Treatment Level Unreported

An estimated 18% did not specify treatment level

Comparison of Availability

CityTreatment CentersInpatient BedsCost of Treatment
St. Louis, MO234~1,800 beds$5,000+/month
Memphis, TN123~900 beds$10,000+/month

Methadone Treatment

What is Methadone

Methadone is an opioid agonist medication used in medication-assisted treatment (MAT) and opioid treatment programs (OTPs). It binds to opioid receptors, reducing cravings and withdrawal symptoms. Society has mixed opinions on methadone treatment—some view it as replacing one addiction with another, while advocates emphasize its efficacy as harm reduction. Put simply, methadone stabilizes patients and enables functioning.

Methadone Distribution

Missouri strictly regulates methadone distribution:

  1. Urine testing: Patients undergo at least eight random drug tests in the first treatment year to ensure compliance.
  2. Take-home doses: Patients are limited to a 24-hour methadone supply for the first 14 days, with more take-homes allowed over time if patients meet certain criteria.
  3. Monitoring: Methadone clinics have interprofessional teams overseeing treatment, including counseling, case management, and care coordination.
  4. Prescription drug monitoring: Clinicians review the PDMP to carefully cross-reference methadone dosage with other medications, as methadone has a narrow therapeutic index and risk of interactions.

Missouri categorizes methadone as a Schedule II controlled substance, indicating potential for abuse and dependence.

Methadone Treatment Effectiveness Research

Methadone has been effectively used to treat opioid addiction since 1947.

Evidence for Effectiveness: Studies show participation in a methadone program is linked to reduced opioid use, infectious disease transmission, and criminal acts:

  • 33% fewer opioid-positive drug tests
  • 4.44 times more likely to stay in treatment

Retention in methadone treatment lowers overdose and disease risks while increasing employment.

Major Drawbacks:

  • Potential for misuse/diversion
  • Severe withdrawal if stopped suddenly
  • Possible QTc prolongation/cardiac issues
  • Respiratory depression/overdose risk when combined with other substances

Comparison to Other Medications: Research shows methadone and buprenorphine have equal effectiveness for reducing illicit opioid use.

About Missouri

Missouri is located in the Midwestern United States, bordering Iowa, Illinois, Kentucky, Tennessee, Arkansas, Oklahoma, Kansas, and Nebraska. The capital and largest city is Jefferson City and Kansas City, respectively. Missouri covers 68,742 square miles of land. Infrastructure includes interstate highways, airports, railroads, inland waterways along the Missouri and Mississippi rivers, and ports along the Missouri River.

Population Statistics

The total Missouri population is approximately 6 million residents.


  • Gender: 51% female, 49% male
  • Age brackets: 23% under 18 years, 61% between 18-64 years, 16% over 65 years


  • Healthcare and social assistance (18% of jobs)
  • Manufacturing (14%)
  • Retail trade (11%)
  • Accommodation and food services (9%)