Methadone Clinics in Greenville

Name rehabsAddressPhone
Greenville Metro Treatment Center602 Airport Road Suite C Greenville, SC 29605(864) 234-7952
Greenville Metro Treatment Center602 Airport Road, Suite C, Greenville, SC 29607(864) 234-7952
Marshall I Pickens Hospital Addlife Addiction Services701 Grove Road Greenville, SC 29605(888) 852-8520
Woodlands Treatment Center155 Brozzini Court Suite E Greenville, SC 29615(864) 288-7636
Woodlands Treatment Center LLC155 Brozzini Court, Suite E, Greenville, SC 29615(864) 288-7636

Rules and Regulations

Greenville adheres to strict federal and state regulations regarding methadone clinics, outlined by the Substance Abuse and Mental Health Services Administration (SAMHSA) and the South Carolina Department of Health and Environmental Control.

Certification Procedures

  • Methadone clinics must be certified by SAMHSA and licensed by the state health department
  • Staff must meet educational and licensing requirements
  • Regular facility inspections enforce safety and treatment standards

Benefits of Medication-Assisted Treatment

Medication-assisted treatment (MAT) with methadone helps individuals with opioid use disorder by:

  • Reducing opioid cravings and withdrawal symptoms
  • Blocking the euphoric effects of other opioids
  • Decreasing the risk of overdose
  • Improving health and social functioning

How Clinics Operate and Their Purpose

Methadone clinics provide daily supervised methadone dosing and counseling to support recovery from opioid addiction. The goal is to help patients gain control over substance use to pursue positive life goals.

Insurance Coverage

Public and private insurance, including Medicaid and Medicare, typically cover methadone treatment. Uninsured patients may qualify for state funding or clinic payment assistance programs.

Drug Use in Greenville

The opioid crisis has been declared a nationwide public health emergency. In Greenville County specifically:

  • There were 156 opioid-involved overdose deaths in 2021
  • The rate of overdose deaths increased by 21% from 2020 to 2021

The most commonly used substances in the county are:

  • Alcohol
  • Marijuana
  • Prescription opioids
  • Heroin
  • Cocaine and crack cocaine

Addiction Treatment Overview

Inpatient Treatment

  • Typically 28-30 days in length
  • 24/7 medical monitoring and counseling
  • Detoxification, group therapy, medication management

Outpatient Treatment

  • 1-5 days per week for several hours per day
  • Provided at clinics, hospitals, or recovery centers
  • Individual and group counseling, medication management

Treatment Level Unreported

  • An estimated 30-40% of patients do not report treatment level
  • Likely a mix of inpatient and outpatient services

Comparison of Treatment Availability

CityTreatment FacilitiesInpatient BedsCost of Treatment

Methadone Treatment

What is Methadone

Methadone is a long-acting opioid agonist medication used to treat opioid use disorder and dependence. As medication-assisted treatment (MAT), methadone helps prevent withdrawal symptoms and drug cravings by activating opioid receptors in the brain, reducing illicit opioid use. Under the opioid treatment program (OTP) model, methadone is dispensed daily in specialized clinics with strict monitoring and regulations to prevent misuse or diversion.

Societal perspectives on methadone treatment are mixed — while it is an evidence-based treatment, some view it as merely replacing one addiction with another. However, properly administered methadone normalizes brain function, allows patients to focus on recovery, and reduces the harm of untreated addiction.

Methadone Distribution

Methadone clinics follow stringent state and federal regulations to prevent misuse:

  • Urine testing: Methadone maintenance patients must undergo at least eight random drug tests in the first year of treatment to detect illicit drug use.
  • Take-home requirements: During the first 14 days of treatment, the take-home supply of methadone is limited to a one-day (24-hour) supply that must be ingested on-site. More take-home doses are permitted over time for stable patients meeting certain criteria.
  • Monitoring: Methadone treatment programs should have an interprofessional team including physicians, nurses, and behavioral health staff monitoring patient progress.
  • Prescription drug monitoring: Clinicians should review prescription drug monitoring program (PDMP) data to carefully cross-reference other opioid medications and dosages, as methadone has a narrow therapeutic window and overdose risk.

In Greenville, methadone is a Schedule II controlled substance subject to South Carolina and federal regulations on manufacturing, distribution, and dispensing of controlled substances.

Methadone Treatment Effectiveness Research

Methadone is an effective medication for treating opioid use disorder that has been used since 1947. Studies show methadone:

  • Reduces opioid use, with 33% fewer opioid-positive drug tests
  • Increases treatment retention 4.44 times more likely to stay in treatment compared to non-medication treatments
  • Reduces disease transmission and criminal behavior

However, methadone does carry risks:

  • Potential for misuse/diversion
  • Severe withdrawal if stopped suddenly
  • Possible QTc prolongation/cardiac issues
  • Respiratory depression/overdose when combined with other substances

Methadone is equally as effective as buprenorphine in reducing illicit opioid use. However, it requires careful patient monitoring and management to maximize benefits and minimize harm.

About Greenville

Location, County & List of Neighboring States

Greenville is located in Greenville County in the state of South Carolina, United States. It borders the states of:

  • North Carolina
  • Georgia

Capital and Largest City

  • Capital of South Carolina: Columbia
  • The largest city in South Carolina: Charleston

Land Area

  • Greenville city land area: 27.9 sq miles
  • Greenville County land area: 795 sq miles


  • Major highways: I-85, I-385
  • Airport: Greenville–Spartanburg International Airport

Population Statistics

Total Population

  • City of Greenville population: 71,732 (2020)
  • Greenville County population: 519,207 (2020)



  • Male: 48%
  • Female: 52%

Age Brackets

  • Under 18 years: 20%
  • 18 to 65 years: 63%
  • Over 65 years: 17%


  • Management/Business/Financial: 13%
  • Sales Related: 11%
  • Office/Administrative Support: 10%