Get addiction help now: (858) 363-8214

get help now

Get addiction help now: (858) 363-8214

get help now

Pharmacological Agents Interacting With Methadone

Time to read: 4 min

Information on NAMA’s website is not
intended as medical advice for individual problems. 

 Appropriate medical professionals
should be consulted regarding addiction and addiction recovery.

 

Pharmacologic
Agents

Clinical
Signs
and Symptoms

Comments

Drugs That Decrease Methadone Levels

Rifampin, phenytoin, carbamazepine, butabarbital
sodium, mephobarbital, phenobarbital, secobarbital, ethanol (chronic),
disulfiram, urinary acidifiers, ascorbic acid

Withdrawal signs

Disulfiram may decrease methadone levels but not
significantly. Not clinically problematic.

Drugs That Increase Methadone Levels

Cimetidine, diazepam, ethanol (acute), fluvoxamine
maleate, ketoconazole, urinary alkalinizers

Increased sedation and other opiate effects

Cimetidine can be used in patients with low trough
methadone levels to prolong action (note: must consider cimetidine
effects on other concurrent medications).

Drugs With Levels Affected by Methadone

Desipramine (DMI), zidovudine (AZT)

Possible increased toxicity of DMI and AZT

Methadone descreases DMI and AZT metabolism; may
increase side effects. Close clinical monitoring needed.

Other Opioid and Analgesic Agents

Naltrexone, malmefene,maloxone, buprenorphine,*
butorphanol,* dezocine,* nalbuphine,* pentazocine,* tramadol

Withdrawal signs

 

 

*

Pain-relievers with opioid-antagonist activity.

Synthetic analgesic (not considered opioid
antagonist, but does decrease levels of opiates).

Data from Stine and Kosten,
Addiction Treatment Forum,
Kalvik et al, and Nillson et al.

This chart
courtesy of MedScape

 
The National Alliance Of Methadone Advocates

 

Similar Posts

  • National Alliance of Methadone Advocates Inc 435 Second Avenue New York, NY 10010      

    ByAdmin
    Admin 09/21/2021

    Membership Application Name:   _______________________________________________________   Mr. ___  Ms. ___  Dr. ___ Organization:  __________________________________________________________________________ Title:  _____________________________________________  Degree(s):  ________________________ Address:  _____________________________________________________________________________ Address:  _____________________________________________________________________________ City:   __________________________________   State:   ____________   Postal Code:   _____________ Email:  ______________________________________  Country:   ________________________________ Home Phone: (____)___________________________   Work Phone:  (____)_______________________ Alternate Phone:  (____)________________________   Fax:  (____)______________________________ If you have email may we send you bulletin alerts electronically. (This will get bulletin alerts to you quicker than usual mail)   Yes  _____   No _____ Types of Membership $_______ Individual Membership   Dues: $25 a…

  • National Alliance for Medication Assisted Recovery

    ByAdmin
    Admin 09/27/2021

    National Alliance for Medication Assisted Recovery CONFIDENTIAL Grievance/Compliment Report All information that is provided will be held strictly confidential in the same manner as the patient protections described in the U.S. Federal Confidentiality Regulations 42 CFR and the Standards for Privacy of Individually Identifiable Health Information (the Privacy Rule) as established by the Department of…

  • Index of library

    ByAdmin
    Admin 01/27/2023

      Name Last modified Size Description   Parent Directory   –     083105_samhsa_inform..> 2013-05-14 09:50 27K     42CFR_part2_code.html 2013-05-14 09:49 118K     42CFR_part8_code.html 2013-05-14 09:50 118K     1997_nih_pr_consensu..> 2020-04-11 14:34 9.5K     2003reuters0704_snif..> 2013-05-14 09:50 7.0K     2004_0108CharlestonG..> 2013-05-14 09:50 5.9K     2004_0109BluefldDail..> 2013-05-14 09:49 6.7K    …

  • Methadone in the Maintenance Treatment of Narcotic Addicts

    ByAdmin
    Admin 04/03/2022

     Note On This Page   Admission Requirements  Homes  Take Home Exceptions  (a) The Food and Drug Administration and the Drug Enforcement Administration recognize that the investigational use of methadone requiring the prolonged maintenance of narcotic dependence as part of a total treatment effort has shown promise in the management and rehabilitation of selected narcotic addicts. It…

  • September is Recovery Month

    ByAdmin
    Admin 11/12/2022

    Get Ready for National Recovery Month in September NAMA declares 2003 THE YEAR OF RECOVERY FOR METHADONE PATIENTS Methadone patients have never been allowed to think of themselves as in recovery. This year the National Alliance of Methadone is declaring Recovery Month “The Year of Recovery for Methadone Patients.” What can you do to make…

  • The Advocacy Training Session

    ByAdmin
    Admin 12/18/2021

      The first training for certification will include a variety of topics to give advocates a well-grounded understanding of methadone treatment, research, regulations and laws that protect methadone patients and programs.   Addiction and Methadone– Tom Payte, MD (Drug Dependence Associates) and Joycelyn Woods, MA. (NAMA) The biological constructs of addiction will be explained in…