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Basic Pharmacology:  How Methadone Works Part 2 Basic Opioid Pharmacology All natural and synthetic opioids exhibit a three dimensional T-shaped configuration (Barchas, Berger, Ciaranello and Elliott, 1977). This T-shaped molecule has two broad hydrophobic surfaces which are at right angles and a methylated nitrogen which is usually charged at physiological pH. The charged nitrogen is…

This chart was prepared by Herman Joseph and Joycelyn Sue Woods and is reprinted from METHADONE TREATMENT WORKS: A COMPENDIUM FOR METHADONE MAINTENANCE TREATMENT Topic Illicit Heroin Addiction Stabilized Methadone Maintenance Onset of action Immediate 30 minutes Duration of action 4 – 6 hours 24 – 36 hours or half-life Route of administration Injection, snorting,…

Education Series Number 10 June 2004 The New Federal Regulations What Do They Mean for Patients? Methadone treatment in the U.S. is changing before our eyes. Some of this change has been rapid; some of it will take years or decades. Some patients have heard about new federal regulations, including an end to automatic dose…

Medication Assisted Treatment (MAT) Advocacy The National Alliance for Medication Assisted Recovery (NAMA-R) holds the view that every individual who believes in Medication Assisted Treatment (MAT) is at least a potential  Certified MAT Advocate (CMA). We encourage all supporters of MAT, patient and non-patient, to become Certified MAT Advocates so that all energies directed toward the advancement of…

Education Series Number 7 August 2003 (Revised) What is Managed Care? Managed care is a complex system that involves the active coordination of, and the arrangement for, the provision of health services and coverage of health benefits. The most common types of Managed Care Organizations (MCOs) include Health Maintenance Organizations (HMOs), Preferred Provider Organizations (PPOs)…