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    Methadone 101

    Admin 07/06/2022

    Course Readings Lesson 1: Brief History of Methadone Maintenance Treatment   A short introduction about how methadone started. The original team consisted of four and included Drs. Dole and Nyswander who were the investigators, Dr. Herman Joseph who did the statistics and Dr. Mary Jeanne Kreek who was a medical student at the time. Lesson 2: Methadone…

  • Blind Dosing

    Admin 05/05/2023

    Methadone maintenance treatment has been the most effective treatment for addiction to heroin resulting the cessation of heroin use and criminal behavior. Prior to the development of methadone maintenance treatment over 28 years ago narcotic addiction was considered incurable and a behavioral disorder under the control of law enforcement. Drs. Dole and Nyswander brought the…

  • The Pharmacology of Opioids

    Admin 04/18/2023

    Basic Pharmacology:  How Methadone Works Part 2 Basic Opioid Pharmacology All natural and synthetic opioids exhibit a three dimensional T-shaped configuration (Barchas, Berger, Ciaranello and Elliott, 1977). This T-shaped molecule has two broad hydrophobic surfaces which are at right angles and a methylated nitrogen which is usually charged at physiological pH. The charged nitrogen is…

  • Methadone Take Home Bottle Recall

    Admin 02/17/2023

    The intent of Bottle Recall initially was to be able to allow patients take home medication and to insure that methadone is not diverted to the streets. However, methadone programs have been giving patients take home medication for years without a serious methadone diversion problem. Furthermore numerous studies have demonstrated that methadone is not a…

  • Denying Methadone Patients Medical Care

    Admin 04/18/2021

    The bias and misunderstandings about methadone as a medication often result in methadone patients being refused medical care (Umbricht-Schneiter, 1994; Zweben and Sorensen, 1988). Another common scenario is that their medication is used to coerce or manipulate methadone patients into medical treatment (Blansfield, 1992). In other areas of medicine such actions would be considered unethical…